Log-in
E-Mail
Passwort
Merken
Passwort vergessen?
Werden Sie kostenlos Mitglied
Anmelden
Anmelden
Neukunde
Unser Angebot
Einstellungen
Einstellungen
Dynamische Kurse 
OFFON

MarketScreener Homepage  >  Aktien  >  Swiss Exchange  >  Idorsia Ltd    IDIA   CH0363463438

IDORSIA LTD

(IDIA)
Meine letzten Aufrufe
Populärste Aktien
  Report  
verzögerte Kurse. Verzögert Swiss Exchange - 22.03. 17:30:40
16.9 CHF   -3.43%
19.02.Aktien Schweiz: Warten auf Impulse
AW
07.02.Aktien Schweiz: SMI bleibt im Seitwärtsmodus
AW
07.02.Idorsia legt Fokus 2018 auf Pipeline - Erwartet 2019 steigende Kosten
AW
ÜbersichtKurseChartsNewsRatingsTermineUnternehmenFundamentaldatenAnalystenschätzungenRevisionenDerivate 
News-ÜbersichtNewsOffizielle PublikationenBranchennachrichtenAnalysten Empfehlungen zu

Idorsia : initiates a multiple-dose efficacy and safety study with cenerimod for the treatment of systemic lupus erythematosus

share with twitter share with LinkedIn share with facebook
share via e-mail
0
07.01.2019 | 07:01

Idorsia Pharmaceuticals Ltd. / Idorsia initiates a multiple-dose efficacy and safety study with cenerimod for the treatment of systemic lupus erythematosus . Verarbeitet und übermittelt durch West Corporation. Für den Inhalt der Mitteilung ist der Emittent verantwortlich. Source: Globenewswire

Allschwil, Switzerland - January 7, 2019
Idorsia Ltd (SIX: IDIA) today announced that the first patient has been enrolled into a multiple-dose study to evaluate the efficacy and safety of cenerimod, a selective S1P1 receptor modulator for the treatment of adults with systemic lupus erythematosus (SLE).

Idorsia is investigating cenerimod, an oral once-daily tablet in patients with lupus. Cenerimod has the potential to add a distinct mechanism to the treatment armamentarium for this underserved patient population.

Martine Clozel, MD and Chief Scientific Officer, commented:
"Cenerimod was selected for development due to its unique properties in experimental models. We believe that a combination of high selectivity for the S1P1 receptor and an attenuated calcium response in endothelial cells are responsible for the excellent preclinical efficacy without bronchoconstrictor or vasoconstrictor side-effects. SLE was selected as the target indication because of the pathogenic role of T and B lymphocytes and antibody production in this disease."

In the Phase 1 program, cenerimod showed marked and sustained circulating lymphocyte lowering effects. A Phase 2 safety study with cenerimod, which investigated the pharmacodynamics, safety and tolerability of cenerimod in adult patients with SLE, has been conducted. The study enrolled 67 patients to receive either 0.5, 1, 2 or 4 mg/day of cenerimod or placebo over a treatment period of 12 weeks. The results of the study showed that cenerimod induces a dose-dependent, sustained reduction in circulating lymphocyte counts that was reversible after treatment discontinuation. Cenerimod was well tolerated at all dose levels. The occurrence of adverse events was similar in all five treatment groups.

About the study
Cenerimod is being investigated in a multiple-dose study to evaluate its efficacy and safety for the treatment of adult patients with moderately to severely active, autoantibody-positive SLE. The multicenter, randomized, double-blind, placebo-controlled, parallel-group study will enroll around 500 patients, who will be randomized into four cenerimod treatment arms: 0.5, 1, 2, and 4mg once-daily orally or placebo for up to 12 months. Patients will receive study treatment in addition to background SLE therapy. The study aims to validate the appropriate dose, patient population and endpoints for further development in SLE.

Guy Braunstein, MD and Head of Global Clinical Development, commented:

"This study is based on a clinical pharmacology program in healthy volunteers and a Phase 2 safety study in patients with lupus, which showed that cenerimod reduced circulating lymphocytes in a dose-dependent manner and was safe and well tolerated at doses up to 4 mg. It has been designed to include input from health authorities. As background therapy may confound the treatment effect, the protocol recommends keeping SLE medications as stable as possible during the double-blind treatment period. The study also considers important patient perspectives, such as the overall quality of life and debilitating symptoms like fatigue."

Notes to the editor

About systemic lupus erythematosus
SLE - known more simply as "lupus" since it is the most common form of lupus - is an autoimmune disease, which means that the body's immune system malfunctions and attacks the body's own tissues, causing inflammation and organ damage. Some autoimmune diseases affect individual organs, but in the case of lupus, most parts of the body can be affected: most commonly the skin, joints, gut, blood cells, and lungs, as well as the brain, heart, and kidneys.

Lupus can range from mild to life-threatening and can randomly become worse (so-called 'flare ups') and then better again, which can make living with lupus unpredictable and its impact on day-to-day life wide-ranging. Around five million people worldwide have a form of lupus and while it affects people of all races, genders, and ages, as much as ninety percent of diagnosed cases are in women. The condition is also more common in people of Afro-Caribbean and Asian origin compared to Caucasians and is likely to affect these ethnic groups more severely.

There is no cure for lupus. Most people with lupus are prescribed a combination of different medications including anti-inflammatory, anti-malarial drugs, corticosteroids, immunomodulators.

About cenerimod in systemic lupus erythematosus
How and why lupus affects the immune system's defense mechanisms is still not fully understood. However, T and B lymphocytes are considered the key immune system cells that contribute to the symptoms of the disease, because their normal development and mechanism for developing tolerance to the body's own tissues has malfunctioned in lupus.

T and B lymphocytes have receptors on the surface called "Sphingosine-1-phosphate receptor 1" (S1P1). This receptor senses the gradient of sphingosine-1-phosphate or S1P, which is high in blood, guiding the lymphocytes out of lymph nodes towards the circulation.

Cenerimod, a selective S1P1 receptor modulator, binds to the S1P1 receptor on the surface of T and B lymphocytes. This interaction leads to internalization of the S1P1 receptor, so that the lymphocyte can no longer sense S1P. As a result, the lymphocytes are held in the lymph nodes, reducing the availability of these key players in inflammation to the affected organs and tissues. The effect of cenerimod on lymphocyte trafficking is reflected by the dose-dependent, sustained and reversible reduction in circulating lymphocyte counts observed upon administration of cenerimod.

Key scientific literature
1.        Piali L, et al. Pharmacol Res Perspect. 2017 Dec;5(6).
2.        Borchers AT, et al. Autoimmun Rev. 2010; 9(5):A277-87.
3.        Pons-Estel GJ, et al. Semin Arthritis Rheum. 2010; 39(4):257-68.
4.        Govoni M, et al. Lupus. 2006; 15:110-113.
5.        Rahman A, Isenberg DA. N Engl J Med. 2008; 358:929-39.
6.        Abu-Shakra M, et al. J Rheumatol 1995; 22(7):1259-64.

About Idorsia
Idorsia Ltd is reaching out for more - We have more ideas, we see more opportunities and we want to help more patients. In order to achieve this, we will develop Idorsia into one of Europe's leading biopharmaceutical companies, with a strong scientific core.

Headquartered in Switzerland - a biotech-hub of Europe - Idorsia is specialized in the discovery and development of small molecules, to transform the horizon of therapeutic options. Idorsia has a broad portfolio of innovative drugs in the pipeline, an experienced team, a fully-functional research center, and a strong balance sheet - the ideal constellation to bringing R&D efforts to business success.

Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June 2017 and has over 700 highly qualified specialists dedicated to realizing our ambitious targets.

For further information, please contact
Andrew C. Weiss
Senior Vice President, Head of Investor Relations & Corporate Communications
Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, CH-4123 Allschwil
+41 (0) 58 844 10 10
www.idorsia.com

The above information contains certain "forward-looking statements", relating to the company's business, which can be identified by the use of forward-looking terminology such as "estimates", "believes", "expects", "may", "are expected to", "will", "will continue", "should", "would be", "seeks", "pending" or "anticipates" or similar expressions, or by discussions of strategy, plans or intentions. Such statements include descriptions of the company's investment and research and development programs and anticipated expenditures in connection therewith, descriptions of new products expected to be introduced by the company and anticipated customer demand for such products and products in the company's existing portfolio. Such statements reflect the current views of the company with respect to future events and are subject to certain risks, uncertainties and assumptions. Many factors could cause the actual results, performance or achievements of the company to be materially different from any future results, performances or achievements that may be expressed or implied by such forward-looking statements. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated or expected.




This announcement is distributed by West Corporation on behalf of West Corporation clients.
The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.
Source: Idorsia Pharmaceuticals Ltd. via Globenewswire

--- Ende der Mitteilung ---

Idorsia Pharmaceuticals Ltd.
Hegenheimermattweg 91 Allschwil Schweiz

ISIN: CH0363463438;


share with twitter share with LinkedIn share with facebook
share via e-mail
0
Aktuelle News zu IDORSIA LTD
19.02.Aktien Schweiz: Warten auf Impulse
AW
07.02.Aktien Schweiz: SMI bleibt im Seitwärtsmodus
AW
07.02.Idorsia legt Fokus 2018 auf Pipeline - Erwartet 2019 steigende Kosten
AW
07.02.GNW-NEWS : Idorsia gibt Finanzergebnisse für 2018 bekannt - herausragende Fortsc..
DP
07.02.JEAN-PAUL CLOZEL : Idorsia gibt Finanzergebnisse für 2018 bekannt - herausragend..
GL
05.02.Idorsia rekrutiert ersten Patienten für Phase 3 Studie mit Clazosentan
AW
05.02.GNW-NEWS : Idorsia announces the first patient recruited into REACT - the Phase ..
DP
05.02.IDORSIA : announces the first patient recruited into REACT - the Phase 3 registr..
GL
31.01.GNW-NEWS : Invitation to Idorsia's full year financial results 2018 webcast and ..
DP
31.01.IDORSIA : Invitation to Idorsia's full year financial results 2018 webcast and c..
GL
Mehr News
News auf Englisch zu IDORSIA LTD
07.02.IDORSIA : announces financial results for 2018 - outstanding progress made - fou..
GL
06.02.IDORSIA : announces the first patient recruited into REACT - the Phase 3 registr..
AQ
08.01.IDORSIA : initiates a multiple-dose efficacy and safety study with cenerimod for..
AQ
2018IDORSIA : s P2Y12 receptor antagonist - selatogrel - Phase 2 clinical studies me..
AQ
2018IDORSIA : P2Y12 receptor antagonist - selatogrel - Phase 2 clinical studies meet..
AQ
2018IDORSIA : Santhera enters into agreement to acquire option from Idorsia for excl..
AQ
2018Deal with Idorsia gives Santhera shot at second DMD candidate
AQ
2018IDORSIA : Santhera Enters into Agreement to Acquire Option from Idorsia for Excl..
AQ
2018IDORSIA : Santhera enters into agreement to acquire option from Idorsia for excl..
GL
2018IDORSIA : maintains collaboration agreement with ReveraGen
GL
Mehr News auf Englisch
Finanzkennziffern (CHF)
Umsatz 2019 31,3 Mio
EBIT 2019 -536 Mio
Nettoergebnis 2019 -532 Mio
Schulden 2019 -
Div. Rendite 2019 -
KGV 2019 -
KGV 2020
Marktkap. / Umsatz 2019 70,7x
Marktkap. / Umsatz 2020 39,9x
Marktkap. 2 215 Mio
Chart IDORSIA LTD
Laufzeit : Zeitraum :
Idorsia Ltd : Chartanalyse Idorsia Ltd | MarketScreener
Vollbild-Chart
Trends aus der Chartanalyse IDORSIA LTD
KurzfristigMittelfristigLangfristig
TrendsNeutralFallendFallend
Ergebnisentwicklung
Analystenschätzung
Verkauf
Kaufen
Durchschnittl. Empfehlung AUFSTOCKEN
Anzahl Analysten 3
Mittleres Kursziel 22,3  CHF
Abstand / Durchschnittliches Kursziel 32%
Revisionen zum Gewinn/Aktie
Unternehmensführung
NameTitel
Jean-Paul Clozel Chief Executive Officer & Director
Jean-Pierre Garnier Chairman
André C. Muller Chief Financial Officer & Executive Vice President
Martine Clozel Chief Scientific Officer & Executive VP
Robert J. Bertolini Non-Executive Director
Branche und Wettbewerber
01.01.Marktkap. (M$)
IDORSIA LTD4.19%2 228
GILEAD SCIENCES1.95%81 339
VERTEX PHARMACEUTICALS10.17%46 409
REGENERON PHARMACEUTICALS4.90%42 066
GENMAB8.01%10 747
SAREPTA THERAPEUTICS INC12.03%9 008